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Certain pharmaceuticals enhance antioxidant effects by upregulating Nrf2 expression
In macrophage models, -KG promotes JMJD3-mediated H3K27me3 demethylation, thereby favoring the expression of M2-related genes, whereas succinate accumulation can inhibit demethylase activity and sustain a pro-inflammatory transcriptional state ( It should be noted that most current evidence regarding amino acid-mediated regulation of macrophage polarization is derived from in vitro cell models or animal experiments, whereas systematic validation in human clinical samples remains relatively limited
1 2 3 4 5 6 "Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity"
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Organ-on-a-chip in endometrial research Organoids can be integrated into microfluidic systems, commonly referred to as organ-on-chip (OoC) models, to create advanced platforms for studying the native tissue
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