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Prevents continued benefit and requires cycling to restore normal sensitivity

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Include measurements of body mass and composition (including free-fat mass and adipose tissue changes), food intake with special attention to intake of carbs, proteins and fats, levels of ketosis (measured via blood or breath ketones), potential triggers, medication use, sleep quality, stress levels, and any side effects experienced

Preclinical research, particularly in rodents and nonhuman primates, demonstrates a significant reduction in the intake of alcohol and drugs of abuse following administration of GLP-1 RAs