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The trials used daily supplementation without interruption for 12 months minimum, with the four-year follow-up showing continued improvement

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This hub treats that as safety context rather than a treatment claim, because Melanotan-II is unlicensed and associated with serious adverse events and regulator warnings

Taking it early can support antioxidant protection and help the body manage oxidative stress throughout the day

For negative-mode acquisition, mobile phase A was 100% LCMS-grade H 2 O with 10 mM ammonium acetate, 0.1% ammonium hydroxide and 0.1% medronic acid (Agilent)