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PMID: 39591965 Cell Metab 2019 Jul 2;30(1):157-173.e7

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For FRAA-positive participants, improvement in verbal communication was significantly greater in those receiving folinic acid as compared with those receiving placebo, resulting in an effect of 7.3 (1.4,13.2) standardized points with a large effect size (Cohens d =0.91), indicating that folinic acid treatment may be more efficacious in children with ASD who are FRAA positive

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482,519 Therefore, blocking TGF- signal transduction is a critical strategy in cancer treatment

- Dosage: 2 mg to 5 mg twice per week for the first 4-6 weeks (loading phase), followed by 2 mg once per week (maintenance phase)