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Safety concerns included uncharacterized immunogenicity risks, inadequate impurity and endotoxin testing in available raw material, the unresolved free-base versus acetate salt form distinction, and, for BPC-157 specifically, an angiogenesis mechanism that raises theoretical concerns for patients with undiagnosed tumors
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416 Comparative multiomics analyses between drug-sensitive and drug-resistant PDXs can identify key genetic mutations, pathway rewiring, and phenotypic transitions associated with resistance
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