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Wegovy, Saxenda and Zepbound are approved for weight loss in the following individuals: Adults with an initial BMI of 30, defined as obesity Adults with an initial BMI of 27, defined as overweight, with at least one weight-related comorbid condition Weight-related comorbid conditions include high blood pressure, cardiovascular disease (such as coronary artery disease, heart attack or heart failure), high cholesterol, obstructive sleep apnea, type 2 diabetes, fatty liver, GERD/acid reflux, osteoarthritis, urinary incontinence, etc

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Furthermore, a small population of PPG neurons has been identified within the olfactory bulb with only local projection (Thiebaud et al., 2016)

In SURMOUNT-1, 2,539 adults with obesity, or with overweight and at least one weight-related complication, excluding diabetes, were randomized to once-weekly tirzepatide at 5 mg, 10 mg or 15 mg or to placebo for 72 weeks including a 20-week escalation period