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In separate Phase 2 and Phase 3 trials, retatrutide at 12mg produced greater total body weight reduction than semaglutide at 2.4mg across comparable timeframes, with the difference primarily attributable to retatrutides additional glucagon receptor activation

VashchinkinaEMannerAKVekovischevaOden HollanderBUusi-OukariMAitta-AhoTet al

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Both require fasted administration, so the timing is straightforward