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Data availability All data generated or analysed during this study are included in this published paper and its supplementary information files

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Practical tips for managing gastric emptying-related side effects while maintaining appetite suppression: Eat smaller, more frequent meals instead of three large ones Avoid lying down within two to three hours of eating Prioritize protein-rich foods that support satiety without excessive volume Limit high-fat meals that take longest to empty from the stomach Stay well-hydrated between meals, not during meals Chew food thoroughly to aid digestion Walk for 10-15 minutes after eating to promote gentle gastric motility Appetite suppression by the numbers: what the clinical trials show Let us ground this discussion in the actual data from the major tirzepatide clinical trials

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