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Ghrelin Ghrelin (acyl-ghrelin) is an orexigenic peptide, with the ability to increase both the hedonic and homeostatic aspects of feeding behaviors and is released pre-prandially to stimulate appetite and hunger [for review see ( via the activation of growth hormone secretagog receptor (GHSR, ghrelin receptor), a G-protein coupled receptor with ligand-independent abilities

Patients included in the study mostly noticed a reduction in the formation of wrinkles and the disappearance of fine lines, which were attributed to reversible changes