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[1] [2] Semaglutide works by mimicking the action of the naturally occurring hormone GLP-1, which stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, and reduces appetite
These beneficial effects of GLP-1RA on MACE are independent of many variable including the presence of established CV disease at baseline, the structural basis of GLP-1RA (exendin-4 based agonists vs

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