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While the beneficial effects of low IGF-1 action on aging seems well supported by data in model systems 6,7 and unique human populations 13,16 , a broader examination of the literature suggests that a more nuanced, complex, and controversial relationship exists between IGF-1, aging, and disease, which is indicative of the pleiotropic actions attributed to IGF-1 in cells and tissues 12,19
Rev Invest Clin
In the last decades, a great deal of research aimed at clarifying the role played by GSTs in drug resistance, at developing inhibitors to counteract this activity but also at exploiting GSTs for prodrugs specific activation in cancer cells
The proportion of the dose metabolised by this pathway increases in overdose and, potentially, in the presence of other pathological/physiological states [13, 18,19,20]
Omega-3 Fatty Acids Omega-3 fatty acids are beneficial for overall health and are primarily sourced from marine environments
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