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It has been evaluated in controlled human trials using disease-specific endpoints, with published clinical safety data

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All mild to moderate

A deficiency in Vitamin B12 can cause fatigue and sluggishness, so supplementing with B12 can help increase energy and combat tiredness, which is particularly useful for those on calorie-restricted diets

While B12 is important for overall health and energy, it's not typically the go-to for intentional weight gain

Subcutaneous administration in normal and metabolically dysregulated mice significantly inhibits NNMT activity in metabolically active tissues (adipose, liver, muscle), increases systemic NAD+ levels, enhances mitochondrial function, and improves energy metabolism