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BMI of 30 or higher (obese) BMI of 27+ with weight-related conditions (diabetes, hypertension, high cholesterol) Adults who haven't achieved lasting results with diet and exercise alone Patients committed to lifestyle changes alongside medication Those cleared by a physician after medical evaluation Personal or family history of medullary thyroid carcinoma (MTC) History of Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Active pancreatitis or history of severe pancreatitis Pregnant or planning to become pregnant Patients seeking rapid cosmetic weight loss without medical need Semaglutide FAQ: Naperville References 1.WEGOVY (semaglutide) injection: Highlights of Prescribing InformationU.S

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In type 2 diabetes, preprandial administration of native GLP-1 reduces plasma glucose and improves glucose tolerance [15]

Derived from the proglucagon gene, oxyntomodulin acts as a dual agonist at GLP-1 and glucagon receptors, promoting satiety and increasing energy expenditure ( The subsequent clinical success of engineered dual and triple incretin agonists has reframed these concerns

Acknowledgements We thank all patients and medical staff of Farshchian (Sina) Hospital who contributed to this study