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The scenarios where injectable GLP-1s are clearly superior: A1C above 9.0% (need for maximum efficacy) Established cardiovascular disease (need for proven MACE reduction) Primary goal is weight loss (need for higher semaglutide exposure) Difficulty with medication adherence (weekly is easier than daily for many patients) Unpredictable morning schedule (can't guarantee empty stomach timing) The decision is patient-specific
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Understanding Mazdutides mechanisms is key to appreciating its potential
2024;385:e078523 30
Jall S, Sachs S, Clemmensen C, et al
leukopenia Platelets , or thrombocytes , are involved in the formation of blood clots (ASH 2011)
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