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El envejecimiento, el estrs oxidativo o el uso de ciertos frmacos (estatinas, betabloqueantes) reducen sus niveles endgenos

J., Pecor, L

In Drosophila, the SLC25A39/40 homolog Shawn localizes to mitochondria, and its loss increases ROS accumulation, disrupts mitochondrial function, and causes progressive neurodegeneration 13