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It can be synthesized in the body and plays an important role in the urea cycle in the liver and kidneys, but interestingly is rarely found in foods besides watermelon, which is the primary reason it's so often supplemented 3
One interesting theory Ive heard is that in people with a long history of alcohol-use disorder of heavy drinking that the blood-brain barrier becomes leakier, that its easier for different things to cross into the brain, and that, again, this may be one reason that GLP-1s perhaps are more effective in reducing substance use for people with alcohol-use disorder than other drugs
Mohan M, Al-Talabany S, McKinnie A, Mordi IR, Singh JSS, Gandy SJ, et al
Mounjaro side effects can feel worse in the evening because symptoms build across the day and are often triggered by the largest meal, which tends to be dinner
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