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ECG Recording ECGs were recorded continuously in deeply anesthetized rats for all three main leads, by positioning stainless steel electrodes on all four limbs using an ECG monitor with a 2090 programmer (Medtronic, United States) connected to a Waverunner LT342 digital oscilloscope (LeCroy, United States) at 30 min ligation time
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Among thousands of mitochondrial compounds, one stood out: glutathione
The former work by exerting high GST-inhibitory activity, while the latter comprise inactive compounds designed to target tumor tissue locally by undergoing GST catalysis in the tumor to release cytotoxic metabolites
If the Phase II results are positive, Palatin plans to advance to a larger Phase III trial in 2025
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