IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice [PMID: 25248835] Laboratory literature summary: IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice
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The result can include increased oxidative stress, inflammation, and cellular damage
For instance, increased levels of L-kynurenine have been associated with alterations in white matter integrity, pointing to a potential connection between inflammation-related metabolic pathways and structural brain changes in MDD (Wei et al
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Ferroptosis activation in TGF--treated HK-2 cells is suppressed by GPX4 overexpression Our in vivo studies revealed the role of GPX4 overexpression in attenuating TEC ferroptosis and fibrotic changes during UUO