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For instance, lipids contained in GrDEVs effectively suppress the assembly and activation of NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasomes by blocking Apoptosis-associated speck-like protein containing a CARD (ASC) oligomerization and speck formation, thus reducing IL-1 and IL-18 secretion [148]
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Patients must not self-medicate
A recent study enrolled 104 patients, randomly assigned to receive either obexelimab or placebo
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