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Resolves without intervention in 95% of cases
Patients with homozygosity at this mutated locus tend to exhibit a more severe clinical phenotype, usually associated with severe mental retardation and early onset seizures, and five of them died early in life [6,7,8]
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If you cant quit smoking, you can mitigate this by eating nutritious foods, taking nutritional supplements and receiving a regular vitamin B12 injection
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