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111 In is linked to octreotide using diethylenetriamine pentaacetic acid, while 90 Y and 177 Lu (Lutathera) are linked using tetraazacyclododecane tetraacetic acid as a chelator 68
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PubMed Spooner LM, Olin JL
CJC-1295 with DAC is a tetrasubstituted 30-amino-acid analog of GHRH(1-29) that includes a Drug Affinity Complex (DAC) to extend its half-life through albumin binding
The formulation is particularly valuable for research examining the temporal dynamics of growth hormone release, as the different pharmacokinetic profiles of the two components allow for investigation of both immediate and sustained growth hormone releasing effects
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