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For dogs, it may support skin health, but introducing any new supplement should be done cautiously and preferably under veterinary guidance

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Of these, four were excluded before any attempts at pump implantation (phase 1): one before the initial workup died suddenly owing to poor cardiac status, and three were excluded during the initial workup (owing to mild fluctuations, psychosis during the acute l-dopa administration test and benign brain tumor)

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Moreover, not including trial registries and gray literature in order to maintain the robustness and reliability of our manuscript could also emphasize the publication bias in our study