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In addition, GLP-1RAs, reduce pancreatic islet -cell apoptosis, stimulate the proliferation and differentiation of -cells, and decrease body weight by suppressing food intake in patients with T2DM [8, 41,42,43]

GLP-1 RAs should be considered as an add-on to SGLT2i therapy for those with cardiometabolic complications with elevated HbA1c, BMI 35 kg/m 2 , and comorbidities

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