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Necrosis (centrilobular, midzonal, periportal) might be accompanied by other histological changes (fatty change, congestion, hemorrhage, inflammation, bile stasis, fibrosis, etc.) to form a myriad of pathological changes
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Two downstream consequences are mechanistically central: nicotinamide is preserved for re-entry into the NAD+ salvage pathway (raising intracellular NAD+ availability), and SAM is preserved for other methylation reactions
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This can range from the formation of painful gallstones to severe inflammation (cholecystitis) that often necessitates surgical removal of the gallbladder (cholecystectomy)
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