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Types of outcome measures Primary outcomes Primary outcomes included PD motor impairment as measured by the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) subscale Part III in the on-medication state in endpoints and midpoints of included studies and in the off-medication state in endpoints and midpoints of included studies [19]

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Pre-Cruise Checklist Contact cruise line special needs department 30+ days before sailing Request medi-cooler rental if needed Confirm refrigeration options for your specific ship Pack personal cooler (12x12x12 max) with gel ice packs Bring portable sharps container Medication in original packaging with prescription labels Doctors letter detailing medical needs Extra medication supply (cruise + 5-7 days minimum) Ice in your personal cooler for embarkation day Hotel Accommodations and Refrigeration Securing appropriate medication storage at hotels requires proactive communication without oversharing personal medical details