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Its also a risk factor for many cancer types

First-generation CAR constructs rely on CD3 signaling for T-cell activation, yet lack intracellular costimulatory signals, which limits their in vivo expansion and persistence, impeding a durable anti-tumor response

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Therefore, we investigated the possible mechanism of GLP-1RA action on tumors based on the results of existing studies

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Further chemical and structural investigations of the mosquito melanin-based immune response are encouraged to further elucidate these mechanisms