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Monitor renal function in patients reporting adverse reactions to ZEPBOUND that could lead to volume depletion [see WARNINGS AND PRECAUTIONS ]

After propensity-score matching, 7,091 patients treated with GLP-1 receptor agonists (47% liraglutide, 50% dulaglutide, 3% semaglutide) were compared with an equal number of patients treated with SGLT2 inhibitors (40% dapagliflozin, 10% canagliflozin, 49% empagliflozin)

Some tolerate escalation smoothly, while others require a slower approach

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The accumulation of free radicals over the years can accelerate the aging process

Further in vitro studies in IEC-6 cells revealed that exendin-4 enhanced SERT expression and increased 5-HT reuptake [58] (Fig