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Supporting nutrition and microbiome balance with targeted supplements may help the body adapt to metabolic and hormonal changes during weight loss. Lama Dalloul, clinical dietitian at Bioniq, also shares that thoughtful supplementation can help maintain overall nutritional balance, support muscle health when protein intake is low, aid energy metabolism and cognitive function, and promote gut health and digestion, especially if gastrointestinal side effects occur

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Moreover, treatment with mitochondria-targeted antioxidant MitoQ preserves mitochondrial quality control, alleviates tubular injury, and restores kidney function by reversing mitophagy deficiency through the Nrf2/PTEN-induced kinase 1 (PINK) signaling pathway in db/db mice (68)

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Fasting mice showed increased CREBH-C levels in serum compared to fed mice

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