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For weight-loss medications, Illinois Medicaid's step therapy protocol (as of 2026) works like this: Step 1: Lifestyle modification

Participants on the 12 mg dose lost an average of 28.7% of their body weight

This breakthrough could pave the way for targeted treatments that deliver the benefits of semaglutide with fewer downsides

Source: Reference 1 Data on weight loss of GLP-1R agonists are being continuously refreshed along with the emergence of new iterations of the product

Translated to a weekly pace, the studys data works out to roughly 0.74 pounds lost per week on average, though this varies significantly by individual, starting weight, dose, and adherence

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