Petrelintide, an amylin analog partnered with Roche, is planned to move into Phase III trials for chronic weight management in the second half of 2026
Rapid weight loss alters sex hormone binding globulin levels, which affects free estrogen and progesterone availability
Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists
Meng L, Srivastava AK, Kua K, Wu Q (2022) Earthworm ( Pheretima guillelmi )-mycorrhizal fungi ( Funneliformis mosseae ) association mediates rhizosphere responses in white clover
Regular audits of blinding procedures were conducted to ensure compliance
3 Rybelsus, made by Novo Nordisk, contains oral semaglutide