Notably, the peptide upregulates genes associated with tissue repair and regeneration while simultaneously downregulating genes linked to tissue destruction and inflammatory damage
Neutralizing IL-1 or IL-18 (the inflammasome products) is another approach: Anakinra (IL-1 receptor antagonist) has been used off-label in systemic inflammation settings and is attractive for short-term use around surgery to DAMPsen the IL-1 surge (115)
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