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The therapys approval was based on clinical data from the STEP UP trial programme, in which a 7.2mg dose of Wegovy triggered additional weight loss over previously approved doses in patients with obesity (NCT05646706), while maintaining a similar safety profile
Two main factors drive this regain: Gastric emptying: Semaglutide slows down gastric emptying, which means food stays in your stomach longer, keeping you fuller after eating
According to a study published in Frontiers in Pharmacology, intramuscular administration of vitamin B12 produces a faster increase in serum levels compared to oral routes, although both methods are effective in restoring normal cobalamin levels in patients with deficiency
Pancreatitis : Use with caution if you have a history of pancreatitis
Schulz C, Vezzani C, Kroemer NB
Timing: Take on an empty stomach for best absorption
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