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The intention-to-treat principle: how to assess the true effect of choosing a medical treatment
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In rats with chronic liver failure, brain edema occurred from the combined effects of hyperammonemia and systemic oxidative stress, with allopurinol, a xanthine oxidase inhibitor, treatment attenuating both oxidative stress and brain edema [62]
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As an inducer of ferroptosis, inhibiting CHAC1-induced cell death may also hold therapeutic relevance for conditions like neurodegenerative diseases
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