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Cell culture Human malignant melanoma (A375) cells were obtained from the American Type Culture Collection (ATCC, CRL-1619IG-2) and used within ten passages for all experiments
A few suppliers sell pre-blended cag/tirz vials (most often at a 5 mg / 5 mg ratio or similar), but the dose math is more flexible with separate vials
Both trials were published in the New England Journal of Medicine in June 2025, giving the dataset behind the CagriSema FDA review a peer-reviewed foundation
use with caution
118-123 Specifically, Fitzgerald et al
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