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The CASTOR proteins are arginine sensors for the mTORC1 pathway
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TB-500s composition is the Ac-LKKTETQ fragment of T4, and many claimed effects are inferred from the extensive T4 literature
For survival analysis, AKP tumour-bearing mice were generated as above, and 26 days after induction, they were treated with 150 mg kg 1 5FU (i.p.) 250 mg kg 1 metformin (o.g.) three times weekly
doi: 10.1056/NEJMoa1411892 21 RubinoDMGreenwayFLKhalidUO'NeilPMRosenstockJSrrigRet al
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