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Noteworthy is the increase in cell biomass(protein, nucleic acids and lipid) dependent upon glutaminolysis supported anaplerosis as shown by the increased incorporation of 14C-U-glutamine into cell biomass (Figure 4C).The critical role of GDH flux in cell survival is evident from the massive cell death induced by GDH inhibition under glucose depleted conditions with 100uM EGCG [5,26], an inhibitor of GDH [5]
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Quick Answer: Yes, glutathione can cause diarrhea in some individuals, particularly when taken in high doses or in standard oral capsule forms that are poorly absorbed
PMC 10465717