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Pairing a GHRH analogue with a GHS-R1a agonist is a long-standing design in secretagogue research, following the work of Bowers and colleagues showing that the two classes produce a greater combined response than either alone
BlasiFPageCRossoliniGPallecchiLMateraMRoglianiPet al
demonstrated that although high dose exenatide treatment did not exercise a significant effect on left ventricular function or area at risk, a trend was observed towards a smaller infarct size as percentage of the area at risk in patients with first acute myocardial infarction who were to be treated with primary percutaneous coronary intervention [64]
That said, the side effect profile overlaps significantly with GLP-1 agonistsGI symptoms like nausea, vomiting, and diarrhea are still common, especially during dose escalation
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