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BLACK BOX WARNING: Risk of Thyroid C-Cell Tumors In animal studies, semaglutide caused thyroid C-cell tumors, including medullary thyroid carcinoma (MTC)

Saccol R, da Silveira KL, Manzoni AG, Abdalla FH, de Oliveira JS, Dornelles GL, Barbisan F, Passos DF, Casali EA, de Andrade CM, da Cruz IBM, Leal DBR (2020) Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis

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Retatrutide is an investigational once-weekly subcutaneous peptide that activates GLP-1, GIP, and glucagon receptors simultaneously, aiming to suppress appetite and increase energy expenditure beyond the effect of existing approved agents

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I think you have to balance the risks and the benefits of the drug with what youre trying to treat