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PMID 39025385

Tirzepatide versus Semaglutide for Weight Loss in Obesity (SURMOUNT-5)

Beta-hydroxybutyrate, a marker of fatty acid oxidation, increased by 78% to 181%, confirming that retatrutide drives substantial fat burning at the cellular level

The data says possibly yes

Add in the fact that bloating can make your clothes feel tighter and your body feel heavier, even if the scale hasnt changed, and its easy to see why people with IBS feel like theyre gaining weight, even if some of it is temporary water retention or inflammation

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