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Experimental findings also indicate that thymosin-related peptides can influence macrophage polarization and functional activity, while GHK-Culinked pathways affect inflammatory signaling networks associated with leukocyte mobilization and tissue remodeling (31,33,35)
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It also activates the FAK-paxillin signaling pathway in tendon fibroblasts, promoting cytoskeletal reorganization and directed cell migration both essential steps in connective tissue repair
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This receptor is also expressed, and hence can be studied, in vitro , by the human enteroendocrine cell model NCI-H716 or by the murine GLUTag cell line (320)
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