De Groot AS, Moise L, Terry F, Gutierrez AH, Hindocha P, Richard G, et al
There were concerns about side effects, but Lilly said it did not observe any cardiac or liver issues
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Also report mood changes, sleep disruption, or joint pain that coincides with tirzepatide initiation, as steroids amplify emotional and inflammatory side effects
The authors concluded that retatrutide demonstrated clinically meaningful glucose-lowering and bodyweight-lowering efficacy in adults with type 2 diabetes [2]
You can also report suspected side effects via the MHRA Yellow Card Scheme to help monitor medication safety