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2020;12(533):eaay8071

Rapid weight loss may also increase the risk of losing lean muscle mass if patients are not prioritizing protein intake and resistance training

These are the three important parts of a healthy lifestyle: While limiting calories is required for losing weight, severely restricting calories sets you up for failure because a low-calorie diet is impossible to maintain in the long run

This article addresses the math because the math is the part that can be explained cleanly

Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks

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