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Furthermore, since GSH causes a switch from eumelanin to phaeomelanin, it may increase UV photosensitivity, DNA damage and skin cancers in previously protected populations
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Under homeostatic conditions, transient activation of NRF2 is cytoprotective, allowing for adaptation to various cell intrinsic (i.e., reactive oxygen species (ROS) generated by mitochondrial function) and extrinsic (i.e., xenobiotic) stressors (Kensler et al, 2007
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The RAW files were uploaded to Integrated Proteomics Pipeline (IP2) and searched using the ProLuCID algorithm (publicly available at using a reverse concatenated, non-redundant version of the Mouse UniProt database (release 2017)
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