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A full medical evaluation is required to determine candidacy, review contraindications, and ensure proper dosing and monitoring
FGF21 analogs with balanced receptor agonism and sustained exposure have also been shown to improve glycemic control, ameliorate dyslipidemia and reduce body weight
319,320,321,322 SGLT-is can also reshape gut microbiota, reducing uremic toxins on organs such as heart and kidney 323 and upregulating l-tryptophan which promote secretion of GLP-1
Mechanistic rationale: non-overlapping molecular targets produce complementary tissue repair effects via two distinct biological pathways
Possibly
Microglia also use alternative receptors such as TREM2 (Triggering Receptor Expressed on Myeloid cells 2), which regulates the transition to the DAM phenotype [126, 447]
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