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The receptor is there, the peptide binds, but the downstream cascade doesn't trigger
This gives you objective data to review with your prescriber, rather than relying on memory (which tends to be unreliable for gradual changes)
Dumontel et al
However, when excessive amounts of acetaminophen are ingested, the livers supply of glutathione can be depleted rapidly, leaving NAPQI unneutralized.[ref] Glutathione is the master antioxidant, but there are several situations in which glutathione levels may already be low and thus unable to rise to the occasion for high doses of acetaminophen
doi:10.1093/ehjcvp/pvae074
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