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Exogenously, they arise from exposure to environmental factors like ultraviolet (UV) radiation, pollution, tobacco smoke, and industrial chemicals [3]

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DJ-1 deficiency increases the sensitivity of microglia to dopamine, elevating monoamine oxidase (MAO) activity while reducing TREM2 expression

In parallel, researchers recognized that GLP-1s appetite-suppressing effects could be leveraged to treat obesity

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To induce acute liver injury, 8-week-old NSI mice received two consecutive intraperitoneal injections of DMN (7 mg/kg, Sigma, 1.0% dissolved in saline)