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J., Hui, S
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The activation of TFEB requires modification of a specific lysine residue in the translation initiation factor 5A (eIF-5A) generating what is called hypusine (derived from hy droxy pu trescine and ly sine ) which involves spermidine as outlined in the Polyamines in Protein Modification below
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Such comprehensive stacks require careful monitoring and should only be considered by experienced researchers
18 Intranasal administration of reduced GSH, (in)GSH, could be an effective approach for delivery of GSH to the CNS
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