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The proportion of lean mass loss to fat mass loss has generally been recommended that 25% of the lost weight should be fat free mass the Quarter FFM Rule. [26] Before the advent of these newer medications, excessive loss of fat free mass, and particularly muscle mass, has not been a clinical issue
Published September 2019
Earlier dual-agonist research (combining GLP-1 with glucagon) had explored these benefits but was hampered by hyperglycemia
By activating the GLP-1 pathway, the therapy improves insulin secretion, lowers blood glucose levels, and promotes weight loss
These warnings are not a result of any direct causal link
So if your main concern is weight and you want to stay strictly on-label, Wegovy might be your go-to
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