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Lisdexamfetamine (Vyvanse) is the only medication specifically approved for moderate to severe BED in adults, while GLP-1 agonists may be prescribed off-label based on emerging evidence
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There is some literature of lower DAO levels correlating with symptoms, and blood sample analysis shows there is no consistency in serum DAO levels reflecting intestinal levels of DAOthe primary barrier, as cut-offs and standard assays vary
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1,2 For this reason, its important to further understand the mechanism of GLP-1 therapies, said Lorenzo Leggio, a neuroendocrinologist at the National Institute on Drug Abuse who mediated the GLP-1 press conference at the 2025 Society for Neuroscience meeting
223-225 Refer to individual agent product information for more detail
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