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[2] As of 2019, tesofensine has been discontinued for the treatment of Alzheimer's and Parkinson's disease but is in phase III clinical trial for obesity
This finding highlights not only the key role that mitochondrial metabolism has in modulating response and resistance to TS inhibitors, but the wider opportunity afforded to enhance TS inhibitor-mediated anti-cancer effects by targeting mitochondrial metabolism using metformin or other compounds with similar mitochondrial impact
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It also aids the process of cleansing the body helping the liver clear toxins and heavy metals
The main disadvantages include potential gastrointestinal upset (nausea, vomiting, diarrhoea), particularly when starting oral supplements
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